An experimental study on initial fixation strength in transpedicular screwing augmented with calcium phosphate cement.

STUDY DESIGN

An experimental study.

OBJECTIVE

To clarify the optimal insertion timing of transpedicular screws when the initial fixation strength reaches in maximum as calcium phosphate cement (CPC) hardens, in cases augmented by CPC to the vertebrae.

SUMMARY OF BACKGROUND DATA

CPC goes easily into the bone trabeculae and excels in the bone compatibility. However, it is still unknown as for differences of fixation effects by CPC hardening time at actual insertion of the pedicle screw.

METHODS

Fifty-seven vertebrae obtained from 11 human cadavers. The CPC and titanium pedicle screws were used. Experimental groups were decided as follows. (1) Control group (without CPC). (2) CPC group (augmented with CPC); the mixed CPC infused into the screw hole, afterwards the pedicle screw inserted at a set time (passage time from the initiation of powder and liquid agent mixing). The CPC group was further divided into 3 subgroups, with respect to insertion time of the pedicle screws: 2, 5, and 10 minute subgroups. Maximum pull-out strength was compared, and cross sectioned specimens of the 5 and 10 minute groups were prepared and observed.

RESULTS

CPC group showed a pull-out strength of about 177% that of the control group. For inserting timing of the pedicle screw and pull-out strength, no apparent statistically significant difference was found between each subgroups, although the 10-minute group showed the lowest. Cross sectional observations revealed that the CPC diffused deeper into the bone trabeculae in the 5-minute group than in the 10 minutes.

CONCLUSION

CPC augmentation enabled an average 77% increase of the maximum pull-out strength compared to the control group. The study of screw insertion timing augmented with CPC was indicative of the fact that an increase in the initial fixation of the pedicle screw can be achieved when the screw is inserted before initiation of CPC hardening.