Ligands of diltiazem binding site: an overview of some chemotypes.

R Budriesi, P Ioan, E Carosati, G Cruciani, B S Zhorov, A Chiarini

Journal: Mini reviews in medicinal chemistry 2010;9(12):1379-88

PMID: 19929811

Abstract

The diltiazem binding site of L-type calcium channels is the least characterized to date. In this paper, we present some of the available chemotypes that bind to the benzothiazepine binding site: natural compounds, compounds synthesized by varying the benzothiazepine scaffold, and compounds discovered by means of computational approaches.

Address: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Bologna, Via Belmeloro 6, 40126 Bologna, Italia. [email protected]

DOI: 10.2174/138955709789957369

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MeSH Terms: Binding Sites, Calcium Channel Blockers, Calcium Channels, L-Type, Computer Simulation, Diltiazem, Ligands