Fluorogenic click reaction.

Chao Wang, Qian Wang, Céline Le Droumaguet

Journal: Chemical Society reviews 2010;39(4):1233-9

PMID: 20309483

Full Text on Royal Society of Chemistry View on PubMed

Abstract

Fluorogenic Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions have emerged as a powerful tool for bioconjugation, materials science, organic synthesis and drug discovery. This review highlights the design of the recent development of fluorogenic CuAAC reactions as well as their applications.

Address: Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA.

DOI: 10.1039/b901975h

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https://doi.org/10.1039/b901975h

MeSH Terms: Alkynes, Azides, Catalysis, Copper, Cyclization, DNA, Fluorescent Dyes, Nanoparticles, Polymers, Viruses