The chemistry and biology of LL-37.

Matthew F Burton, Patrick G Steel

Journal: Natural product reports 2009;26(12):1572-84

PMID: 19936387

Full Text on Royal Society of Chemistry View on PubMed

Abstract

LL-37 is a human host defence peptide that has a wide range of biological functions, including antimicrobial and immunomodulatory properties. This review summarises how molecular structure influences the balance between the immunomodulatory and antimicrobial functions of LL-37.

Address: Centre for Bioactive Chemistry, Department of Chemistry, University of Durham, Science Laboratory, South Road, Durham, DH1 3LE, UK. [email protected]

DOI: 10.1039/b912533g

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https://doi.org/10.1039/b912533g

MeSH Terms: Amino Acid Sequence, Antimicrobial Cationic Peptides, Humans, Molecular Sequence Data, Cathelicidins