High altitude hypoxia and oxidative stress: The new hope brought by free radical scavengers.

Xuefeng Li, Juanhong Zhang, Guoan Liu, Guofan Wu, Rong Wang, Junmin Zhang

Journal: Life sciences 2023;336():122319

PMID: 38035993

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Abstract

Various strategies can be employed to prevent and manage altitude illnesses, including habituation, oxygenation, nutritional support, and medication. Nevertheless, the utilization of drugs for the prevention and treatment of hypoxia is accompanied by certain adverse effects. Consequently, the quest for medications that exhibit minimal side effects while demonstrating high efficacy remains a prominent area of research. In this context, it is noteworthy that free radical scavengers exhibit remarkable anti-hypoxia activity. These scavengers effectively eliminate excessive free radicals and mitigate the production of reactive oxygen species (ROS), thereby safeguarding the body against oxidative damage induced by plateau hypoxia. In this review, we aim to elucidate the pathogenesis of plateau diseases that are triggered by hypoxia-induced oxidative stress at high altitudes. Additionally, we present a range of free radical scavengers as potential therapeutic and preventive approaches to mitigate the occurrence of common diseases associated with hypoxia at high altitudes.

Address: College of Life Science, Northwest Normal University, Lanzhou 730070, China.; College of Life Science, Northwest Normal University, Lanzhou 730070, China; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address: [email protected].; College of Life Science, Northwest Normal University, Lanzhou 730070, China. Electronic address: [email protected].; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China; Key Laboratory for Prevention and Remediation of Plateau Environmental Damage, 940th Hospital of Joint Logistics Support Force of CPLA, Lanzhou 730050, China. Electronic address: [email protected].; School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address: [email protected].

DOI: 10.1016/j.lfs.2023.122319

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MeSH Terms: Humans, Free Radical Scavengers, Altitude Sickness, Altitude, Oxidative Stress, Hypoxia, Antioxidants