Seizures and EEG findings in an adult patient with DiGeorge syndrome: a case report and review of the literature.

Walter González, Ramon Edmundo D Bautista

Journal: Seizure 2009;18(9):648-51

PMID: 19665396

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Abstract

This is the first case report to describe the EEG findings in a patient with DiGeorge syndrome who survived into adulthood. The patient developed generalized tonic-clonic seizures when she was 9 years old and these were associated with hypocalcemia. Despite treatment with calcium, seizures persisted and the patient required antiepileptic medications. She was eventually controlled with oxcarbazepine. An MRI of the head was normal. An EEG showed independent spike and wave discharges emanating from the left temporal and right frontal region. The presence of focal findings on EEG, the lack of complete response to calcium therapy, and the need for antiepileptic drug therapy indicate that some of these patients may be inherently predisposed to developing epilepsy.

Address: Department of Neurology, University of Florida Health Science Center/Jacksonville, Jacksonville, FL 32209, United States.

DOI: 10.1016/j.seizure.2009.07.003

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MeSH Terms: Age of Onset, Anticonvulsants, Brain, Calcium, Child, DiGeorge Syndrome, Electroencephalography, Female, Humans, Hypocalcemia, Magnetic Resonance Imaging, Seizures, Young Adult