The origin of the genetic code and of the earliest oligopeptides.

Edward N Trifonov

Journal: Research in microbiology 2009;160(7):481-6

PMID: 19524038

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Abstract

Reconstruction of the earliest proteins in the ancient binary alphabet [glycine family G, alanine family A] leads to repeats of G alternating with repeats of A. In addition, omnipresent motifs can be assembled in two of the earliest genes involved in energy supply, crucial for Life, i.e. ATP/GTP binding and ATPase activity. They are an almost perfect match to the alternating G and A and are complementary to each other.

Address: Genome Diversity Center, Institute of Evolution, University of Haifa, Mount Carmel, Haifa 31905, Israel. [email protected]

DOI: 10.1016/j.resmic.2009.05.004

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MeSH Terms: Adenosine Triphosphate, Amino Acid Motifs, Binding Sites, Biological Evolution, Catalytic Domain, Genetic Code, Guanosine Triphosphate, Oligopeptides