Baicalin suppresses expression of Chlamydia protease-like activity factor in Hep-2 cells infected by Chlamydia trachomatis.

Huang Hao, Yang Aixia, Li Dan, Fu Lei, Yu Nancai, Su Wen

Journal: Fitoterapia 2009;80(7):448-52

PMID: 19524644

Full Text on Elsevier Science View on PubMed

Abstract

In this study, we tested the ability of Baicalin to block Chlamydia trachomatis infection and found that the Baicalin blocked infection of Hep-2 cells. Then, we looked into the expression of RFX5 and CPAF gene in Chlamydia-infected cells. We found that RFX5 and CPAF were up-regulated and down-regulated respectively by Baicalin. Since CPAF is responsible for degrading RFX5, we suggest that CPAF was a primary target of Baicalin and played an important role in regulating RFX5. Our findings demonstrate that Baicalin can inhibit C. trachomatis effectively and therefore, can be considered as potential agents for therapy of Chlamydia infectious diseases.

Address: Center of Experimental Medicine, Wuhan No.1 Hospital, Wuhan 430022, PR China. [email protected]

DOI: 10.1016/j.fitote.2009.06.004

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MeSH Terms: Anti-Bacterial Agents, Cell Line, Chlamydia Infections, Chlamydia trachomatis, Flavonoids, Gene Expression, Gene Expression Regulation, Genes, Bacterial, Humans, Phytotherapy, Plant Extracts, RNA, Messenger, Scutellaria baicalensis