Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial.

M Mistrangelo, S Cornaglia, M Pizzio, R Rimonda, G Gavello, I Dal Conte, A Mussa

Journal: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2011;12(8):799-803

PMID: 19548899

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Abstract

AIM

Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence.

METHOD

A randomized controlled study was carried out including 261 patients allocated to surgical excision alone (control group; n = 122) and surgical excision plus postoperative immunostimulation for 30 days with a natural product (STET; study group; n = 139). Patients with HIV positivity were excluded. All patients gave fully informed consent.

RESULTS

The patients were followed for 6 months after surgery. Recurrence occurred in 7.2% (10/139) in the study group and in 27.1% (33/122) in the control group (P < 0.0001). There were no significant differences in the sex, sexual orientation, number of lesions, time to diagnosis and treatment or localization of lesions in the two groups.

CONCLUSIONS

Immunostimulation using a natural product significantly reduced the incidence of recurrence of anal condylomata in patients undergoing surgical excision.

Address: Oncological Surgical Department, University of Turin, 10126 Turin, Italy. [email protected]

DOI: 10.1111/j.1463-1318.2009.01960.x

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MeSH Terms: Adjuvants, Immunologic, Adolescent, Adult, Andrographis, Anus Diseases, Carica, Child, Citrus paradisi, Condylomata Acuminata, Echinacea, Female, Humans, Male, Middle Aged, Phytotherapy, Plant Preparations, Prospective Studies, Secondary Prevention, Statistics, Nonparametric, Tabebuia, Uncaria, Young Adult