Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis.

Bryan McGee, Reynaldo Dietze, David Jamil Hadad, Lucilia Pereira Dutra Molino, Ethel Leonor Noia Maciel, W Henry Boom, Moises Palaci, John L Johnson, Charles A Peloquin

Journal: Antimicrobial agents and chemotherapy 2009;53(9):3981-4

PMID: 19564361

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Abstract

Nineteen adults with pulmonary tuberculosis received linezolid (600 mg) once or twice daily in an early bactericidal activity trial. A one-compartment population model produced median values for the absorption rate constant, volume of distribution, and elimination rate constant of 1.5 h(-1), 29.6 liters, and 0.25 h(-1) (once daily) and 2.7 h(-1), 32.1 liters, and 0.15 h(-1) (twice daily). Linezolid administered twice daily produced higher values for free drug area under the concentration-time curve (AUC)/MIC and time above MIC. Both regimens achieved free AUC/MIC ratios > 100. Median times above the MIC for free drug were 100% (twice daily) and 63% (once daily).

Address: Infectious Disease Pharmacokinetics Laboratory, National Jewish Health, Denver, Colorado, USA.

DOI: 10.1128/AAC.01378-08

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MeSH Terms: Acetamides, Adolescent, Adult, Anti-Bacterial Agents, Drug Administration Schedule, Female, Humans, Linezolid, Male, Middle Aged, Oxazolidinones, Tuberculosis, Pulmonary, Young Adult