Assessment of quality of life in Mexican patients suffering from chronic venous disorder - impact of oral Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid treatment - 'QUALITY Study'.

J J Guex, D M E Enriquez Vega, L Avril, S Boussetta, C Taïeb

Journal: Phlebology 2009;24(4):157-65

PMID: 19620698

Abstract

OBJECTIVES

The present study assessed the effect of Ruscus aculeatus-hesperidin-methyl-chalcone-ascorbic acid (HMC-AA) on the quality of life (QoL) of patients suffering from chronic venous disorders (CVDs).

METHODS

An observational, multicentre and prospective study was performed with 917 Mexican patients suffering from CVD. Patients were treated with R. aculeatus-HMC-AA. After 12 weeks of treatment, the physicians then assessed the patients' symptoms and QoL using Short Form (SF-12) and Chronic Venous Insufficiency (CIVIQ) auto-questionnaires.

RESULTS

Patients were mainly women (86.7%), overweight or obese (72.7%) or C2 (39.3%)-C3 (27.6%). All symptoms and ankle circumferences significantly improved over time, with increasing clinical, aetiological, anatomical and pathophysiological (CEAP) classes and body mass index (BMI) (P < 0.001). Concerning QoL, all dimensions of the SF-12 score significantly improved over time (P < 0.001). Moreover, the CIVIQ scores significantly improved (P < 0.001) with increasing BMI (P < 0.002) and CEAP classes (P < 0.05).

CONCLUSION

R. aculeatus-HMC-AA significantly improved the symptoms and QoL of CVD patients.

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DOI: 10.1258/phleb.2009.008066

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MeSH Terms: Administration, Oral, Adult, Ascorbic Acid, Body Mass Index, Chalcone, Chronic Disease, Drug Therapy, Combination, Female, Hesperidin, Humans, Male, Mexico, Middle Aged, Obesity, Plant Extracts, Prospective Studies, Quality of Life, Ruscus, Surveys and Questionnaires, Vascular Diseases