Relationship between hypovitaminosis D and sarcopenia in patients with stage 3 and 4 chronic kidney disease in Colombian patients.

Miguel Alvarez Mejía, Felipe Marulanda Mejía, Clara H González Correa, Cesar A Restrepo Valencia, Pamela Gómez Tobón, José A Chacón

Journal: Clinical nutrition ESPEN 2023;57():519-526

PMID: 37739701

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Sarcopenia is a condition associated with aging and multiple medical conditions such as CKD and hypovitaminosis D.

METHODS

An observational cross-sectional study was carried out, based on patients registered in a database of specialized nephrology consultation in the city of Manizales, Colombia. 101 patients over 18 years of age who had stage 3 or 4 CKD were included.

RESULTS

The frequency of sarcopenia was 10.9%. No relationship was found between sarcopenia alone and serum vitamin D levels. However, when sarcopenia was categorized as severe there was a direct relationship with hypovitaminosis D. There was also a direct relationship between dynapenia and hypovitaminosis D. In addition, patients who had serum vitamin D levels above 40 ng/ml had better muscle performance, and, consequently, probably a lower risk of frailty.

CONCLUSION

When patients, within their treatment, received vitamin D supplementation, no effect on muscle performance was observed.

Address: Clinical Department, Faculty of Health Sciences, University of Caldas, Manizales, Colombia. Electronic address: [email protected].; Clinical Department, Faculty of Health Sciences, University of Caldas, Manizales, Colombia.; Department of Basic Health Sciences, Faculty of Health Sciences, University of Caldas, Manizales, Colombia.

DOI: 10.1016/j.clnesp.2023.06.022

Link outs

Free resources

Medical:

https://medlineplus.gov/vitaminddeficiency.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Adolescent, Adult, Colombia, Sarcopenia, Cross-Sectional Studies, Vitamin D Deficiency, Vitamin D, Renal Insufficiency, Chronic