Adenosine A receptors and sleep.

Mustafa Korkutata, Michael Lazarus

Journal: International review of neurobiology 2023;170():155-178

PMID: 37741690

Full Text on Elsevier Science View on PubMed

Abstract

Adenosine, a known endogenous somnogen, induces sleep via A and A receptors. In this chapter, we review the current knowledge regarding the role of the adenosine A receptor and its agonists, antagonists, and allosteric modulators in sleep-wake regulation. Although many adenosine A receptor agonists, antagonists, and allosteric modulators have been identified, only a few have been tested to see if they can promote sleep or wakefulness. In addition, the growing popularity of natural sleep aids has led to an investigation of natural compounds that may improve sleep by activating the adenosine A receptor. Finally, we discuss the potential therapeutic advantage of allosteric modulators of adenosine A receptors over classic agonists and antagonists for treating sleep and neurologic disorders.

Address: Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].; International Institute for Integrative Sleep Medicine (WPI-IIIS) and Institute of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address: [email protected].

DOI: 10.1016/bs.irn.2023.04.007

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MeSH Terms: Humans, Receptor, Adenosine A2A, Adenosine, Sleep