Mechanism of ribosome assisted protein folding: a new insight into rRNA functions.

Dibyendu Samanta, Anindita Das, Arpita Bhattacharya, Arunima Basu, Debasis Das, Chanchal DasGupta

Journal: Biochemical and biophysical research communications 2009;384(2):137-40

PMID: 19401192

Full Text on Elsevier Science View on PubMed

Abstract

The peptidyl transferase center (PTC), present in the domain V of 23S rRNA of bacteria can act as a general protein folding modulator. Any general function of a nucleic acid polymer (DNA or RNA) is always related to specific sequence/sequences. The ribosome mediated protein folding also involves a specific interaction between the nucleotides of peptidyl transferase center and the amino acids of an unfolded protein. In this article the mechanism of rRNA assisted protein folding and its significance in the light of high resolution crystal structure of ribosome are discussed.

Address: Department of Biophysics, Molecular Biology and Genetics, University College of Science, Kolkata 700009, India. [email protected]

DOI: 10.1016/j.bbrc.2009.04.106

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MeSH Terms: Bacteria, Crystallography, Escherichia coli, Nucleic Acid Conformation, Peptidyl Transferases, Protein Folding, RNA, Ribosomal, 23S, Ribosomes