The calcium/NFAT pathway: role in development and function of regulatory T cells.

Masatsugu Oh-hora, Anjana Rao

Journal: Microbes and infection 2009;11(5):612-9

PMID: 19375514

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Abstract

Calcium signals are essential for diverse cellular functions in the immune system. Sustained Ca(2+) entry is necessary for complete and long-lasting activation of calcineurin/NFAT pathways. A growing number of studies have emphasized that Ca(2+)/calcineurin/NFAT pathway is crucial for both development and function of regulatory T cells.

Address: Department of Pathology, Harvard Medical School and Immune Disease Institute, Boston, MA 02115, USA. [email protected]

DOI: 10.1016/j.micinf.2009.04.008

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https://linkinghub.elsevier.com/retrieve/pii/S1286...
https://pmc.ncbi.nlm.nih.gov/articles/pmid/1937551...
https://europepmc.org/abstract/MED/19375514

Miscellaneous:

https://assays.cancer.gov/CPTAC-177

MeSH Terms: Calcineurin, Calcium, Humans, Models, Biological, NFATC Transcription Factors, T-Lymphocytes, Regulatory