Association of pancreatic autoantibodies and human leukocyte antigen haplotypes with resolution of diabetes mellitus after therapy for hepatitis C virus infection in patients with HIV infection: case report and review of literature.

Yi-Chun Lo, Sui-Yuan Chang, Wang-Huei Sheng, Chien-Ching Hung, Shan-Chwen Chang

Journal: European journal of gastroenterology & hepatology 2010;21(4):478-81

PMID: 19369830

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Abstract

Diabetes mellitus (DM) is a well known complication of interferon therapy for chronic hepatitis C virus (HCV) infection, but resolution of interferon-induced DM was rarely reported. In HIV and HCV co-infected patients, only two cases of incident DM during interferon therapy were reported and both cases required permanent insulin treatment. We report the first case of HIV/HCV co-infected patient who developed diabetic ketoacidosis during treatment for chronic HCV infection with complete resolution of DM after treatment cessation. Review of reported cases indicates that pancreatic autoantibodies and human leukocyte antigen haplotypes may predict the outcome of interferon-induced diabetes.

Address: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

DOI: 10.1097/MEG.0b013e328317f4c8

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MeSH Terms: Adult, Antiviral Agents, Autoantibodies, Diabetes Mellitus, Type 2, HIV Infections, HIV-1, HLA-D Antigens, Haplotypes, Hepatitis C, Chronic, Humans, Interferon alpha-2, Interferon-alpha, Male, Pancreas, Polyethylene Glycols, Recombinant Proteins, Remission, Spontaneous