The new role of calcimimetics as vasculotropic agents.

Ziyad Al-Aly

Journal: Kidney international 2009;75(1):9-12

PMID: 19092812

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Abstract

The discovery of the calcium-sensing receptor (CaSR) and the development of calcimimetics have provided new insights into calcium homeostasis and new therapeutic opportunities for parathyroid-related disorders. However, the CaSR is also implicated in various other cellular processes, and the translational applications of calcimimetics may not be exclusively calcium-centric. Koleganova et al. describe a novel role for calcimimetics as vasculotropes, which provides the impetus for further studies to characterize their effects on vascular biology.

Address: Division of Nephrology, Saint Louis Veterans Affairs Medical Center, Saint Louis, Missouri, USA.

DOI: 10.1038/ki.2008.563

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MeSH Terms: Aniline Compounds, Calcinosis, Calcium, Cardiovascular Diseases, Cinacalcet, Humans, Naphthalenes, Phenethylamines, Propylamines, Receptors, Calcium-Sensing