P-170 peptides with low similarity to the human proteome: tracing an effective and safe biological way towards effective and safe cancer chemotherapy.

Roberto Mazzanti, Darja Kanduc, Giuseppe Novello

Journal: Journal of experimental therapeutics & oncology 2010;8(2):151-5

PMID: 20192121

Abstract

We propose low-similarity P-170 peptide-based antibodies to neutralize the multidrug resistance phenomenon and, consequently, improve the treatment regimens for cancer chemotherapy. As a first step in the experimental validation of this approach, we report on the similarity analysis of the P-170 primary amino acid structure versus the human proteome and describe peptide motifs uniquely owned by the human P-170 glycoprotein.

Address: Department of Biochemistry and Molecular Biology "Ernesto Quagliariello", University of Bari, Italy. [email protected]

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Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Amino Acid Sequence, Antibodies, Blocking, Antineoplastic Agents, Databases, Protein, Drug Resistance, Multiple, Drug Resistance, Neoplasm, Epitopes, Glycoproteins, Humans, Molecular Sequence Data, Peptide Fragments, Proteome