Long-term lithium therapy leading to hyperparathyroidism: a case report.

Nancy D Perrier, Mian M Rizwan

Journal: Perspectives in psychiatric care 2009;45(1):62-5

PMID: 19154241

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Abstract

PURPOSE

This paper reviews the effect of chronic lithium therapy on serum calcium level and parathyroid glands, its pathogenesis, and treatment options. We examined the case of a lithium-treated patient who had recurrent hypercalcemia to better understand the disease process.

CONCLUSION

Primary hyperparathyroidism is a rare but potentially life-threatening side effect of long-term lithium therapy. Careful patient selection and long-term follow-up can reduce morbidity.

PRACTICAL IMPLICATIONS

As much as 15% of lithium-treated patients become hypercalcemic. By routinely monitoring serum calcium levels, healthcare providers can improve the quality of life of this patient group.

Address: Department of Pediatric Surgery, Texas Children's Hospital, Houston, TX, USA. [email protected]

DOI: 10.1111/j.1744-6163.2009.00201.x

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MeSH Terms: Aged, Antimanic Agents, Bipolar Disorder, Calcium, Female, Humans, Hypercalcemia, Hyperparathyroidism, Primary, Lithium Carbonate, Long-Term Care, Male, Parathyroid Hormone, Parathyroidectomy, Thyroidectomy