Advanced search

Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors.

Camilla Scarpellini, Greta Klejborowska, Caroline Lanthier, Behrouz Hassannia, Tom Vanden Berghe, Koen Augustyns

Journal: Trends in pharmacological sciences 2023;44(12):902-916

PMID: 37770317

Free Full Text on Elsevier Science View on PubMed

Abstract

Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic radical-trapping antioxidants (RTAs) reported to block ferroptosis and it is widely used as reference compound. Ferroptosis has been linked to multiple diseases and the use of its inhibitors could have therapeutic potential. Although, novel biochemical pathways provide insights for different pharmacological targets, the use of lipophilic RTAs to block ferroptosis remains superior. In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of their chemical, pharmacokinetic, and pharmacological properties and potential for in vivo use is provided.

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Address: Laboratory of Medicinal Chemistry, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium.; Ferroptosis and Inflammation Research Team, VIB-UGent Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium; Pathophysiology Lab, Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium.; Laboratory of Medicinal Chemistry, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium. Electronic address: [email protected].
DOI: 10.1016/j.tips.2023.08.012

Link outs

Free resources

Full Text Sources:

Other Literature Sources:

Subscription / membership required

Full Text Sources:

MeSH Terms: Humans, Ferroptosis, Lipid Peroxidation, Cyclohexylamines, Antioxidants
Bant logo

© Copyright 2026, Nutrition Evidence

NED wishes to thank the following organisations for their support:

Sponsor Sponsor Sponsor Sponsor Sponsor Sponsor Sponsor

We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.