d-Amino acids: new clinical pathways for brain diseases.

Isis Nem de Oliveira Souza, Robin Roychaudhuri, Jacqueline de Belleroche, Jean-Pierre Mothet

Journal: Trends in molecular medicine 2023;29(12):1014-1028

PMID: 37770379

Full Text on Elsevier Science View on PubMed

Abstract

Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling molecules in many organs, including the brain and endocrine systems. There has been considerable progress in our understanding of the fundamental roles of these atypical messengers, with increasingly recognized implications in a wide range of neuropathologies, including schizophrenia (SCZ), epilepsy, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), substance abuse, and chronic pain, among others. Research has enabled the discovery that d-serine, d-aspartate and more recently d-cysteine are essential for the healthy development and function of the central nervous system (CNS). We discuss recent progress that has profoundly transformed our vision of numerous physiological processes but has also shown how d-AAs are now offering therapeutic promise in clinical settings for several human diseases.

Address: Biophotonics and Synapse Physiopathology Team, Laboratoire LuMIn UMR9024 Université Paris-Saclay, ENS Paris-Saclay, CNRS, CentraleSupelec, 91190 Gif-sur-Yvette, France; Molecular Pharmacology Laboratory, Biomedical Sciences Institute, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Birth Defects, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; Neurogenetics Group, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.; Biophotonics and Synapse Physiopathology Team, Laboratoire LuMIn UMR9024 Université Paris-Saclay, ENS Paris-Saclay, CNRS, CentraleSupelec, 91190 Gif-sur-Yvette, France. Electronic address: [email protected].

DOI: 10.1016/j.molmed.2023.09.001

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MeSH Terms: Humans, Amino Acids, Critical Pathways, Central Nervous System, Brain, Alzheimer Disease