Effectiveness of combination use of antibiotic-loaded PerOssal with spinal surgery in patients with spondylodiscitis.

Dietrich von Stechow, M A Rauschmann

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 2010;43(3):298-305

PMID: 19684405

Full Text on S. Karger AG, Basel, Switzerland View on PubMed

Abstract

Degradable composites of calcium sulphate and nanoparticulate hydroxyapatite (PerOssal) have shown promising results in vitro. Here we investigated the handling, efficacy and compatibility of PerOssal when loaded with gentamicin or vancomycin in 19 patients with spondylodiscitis in vivo. So far, 12 patients who were followed up over at least 1 year have shown a normalization of the infection parameters, no more bone loss in the affected regions and a bony fusion after 3-6 months postoperatively. No revision surgery was related to the use of PerOssal. Locally there were no signs of an ongoing infection. This study demonstrates encouraging results regarding handling, resorption, biocompatibility and antibiotic release using PerOssal pellets in vivo.

Address: Department of Orthopaedic Surgery, University Hospital, Frankfurt/Main, Germany. [email protected]

DOI: 10.1159/000233525

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https://doi.org/10.1159/000233525

MeSH Terms: Adult, Aged, Anti-Bacterial Agents, Calcium Sulfate, Discitis, Drug Therapy, Combination, Durapatite, Female, Gentamicins, Humans, Male, Middle Aged, Nanoparticles, Prospective Studies, Treatment Outcome, Vancomycin