Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions.

Delfine Cheng, Junfan Wang, Mingxi Yao, Charles D Cox

Journal: Biochemical Society transactions 2023;51(5):1897-1906

PMID: 37772664

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Abstract

Both integrin-mediated focal adhesions (FAs) and mechanosensitive ion channels such as PIEZO1 are critical in mechanotransduction processes that influence cell differentiation, development, and cancer. Ample evidence now exists for regulatory crosstalk between FAs and PIEZO1 channels with the molecular mechanisms underlying this process remaining unclear. However, an emerging picture is developing based on spatial crosstalk between FAs and PIEZO1 revealing a synergistic model involving the cytoskeleton, extracellular matrix (ECM) and calcium-dependent signaling. Already cell type, cell contractility, integrin subtypes and ECM composition have been shown to regulate this crosstalk, implying a highly fine-tuned relationship between these two major mechanosensing systems. In this review, we summarize the latest advances in this area, highlight the physiological implications of this crosstalk and identify gaps in our knowledge that will improve our understanding of cellular mechanosensing.

Address: The Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Kensington, NSW 2052, Australia.; Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China.; Guangdong Provincial Key Laboratory of Advanced Biomaterials, Southern University of Science and Technology, Shenzhen 518055, China.; The Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia.; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Kensington, NSW 2052, Australia.

DOI: 10.1042/BST20230042