How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane.

Chikashi Toyoshima

Journal: Biochimica et biophysica acta 2009;1793(6):941-6

PMID: 19010358

Free Full Text on Elsevier Science View on PubMed

Abstract

Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a >10,000 fold concentration gradient across the membrane. Its crystal structures have been determined for 9 different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, with emphasis on why the structure has to be so.

Address: Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. [email protected]

DOI: 10.1016/j.bbamcr.2008.10.008

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https://assays.cancer.gov/CPTAC-177

MeSH Terms: Aspartic Acid, Binding Sites, Calcium, Cell Membrane, Models, Molecular, Protein Structure, Tertiary, Sarcoplasmic Reticulum, Sarcoplasmic Reticulum Calcium-Transporting ATPases