Antibiotic prophylaxis for orthognathic surgery: a prospective, comparative, randomized study between amoxicillin-clavulanic acid and penicillin.

Pornchai Jansisyanont, Somchai Sessirisombat, Panunn Sastravaha, Pimol Bamroong

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2009;91(11):1726-31

PMID: 19127796

Abstract

OBJECTIVE

The present study was designed to evaluate the prophylactic efficacy after the correction of dentofacial deformities between short- and long-term penicillin and amoxicillin-clavulanic acid.

MATERIAL AND METHOD

The present study was prospective, randomized, and double blinded. Patients were separated into four groups randomly: short-term and long-term (5 days) penicillin and short-term and long-term (5 days) amoxicillin-clavulanic acid.

RESULTS

One hundred twenty two patients were assigned randomly into the four groups. Infection developed in a patient in the short-term amoxicillin-clavulanic acid group and in a patient in the long-term penicillin group.

CONCLUSION

There were no differences in infection between the two groups of antibiotics. Based on the present study, short-term penicillin is still the most appropriate choice for prophylactic antibiotic in orthognathic surgery.

Address: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand. [email protected]

Link outs

Free resources

Medical:

MeSH Terms: Adolescent, Adult, Amoxicillin-Potassium Clavulanate Combination, Anti-Bacterial Agents, Antibiotic Prophylaxis, Bacterial Infections, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Osteotomy, Penicillins, Postoperative Complications, Preoperative Care, Prognathism, Prospective Studies, Temporomandibular Joint, Young Adult