Discovery of new therapeutic targets by the informational spectrum method.

Nevena Veljkovic, Sanja Glisic, Jelena Prljic, Vladimir Perovic, Maurizio Botta, Veljko Veljkovic

Journal: Current protein & peptide science 2008;9(5):493-506

PMID: 18855700

Abstract

The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of proteins, in identification of functional protein domains representing candidate therapeutic targets for drugs against human immunodeficiency virus (HIV)-1, anthrax, highly pathogenic influenza virus H5N1 and cardiovascular diseases.

Address: Center for Multidisciplinary Research, Institute of Nuclear Sciences VINCA, Belgrade, Serbia.

DOI: 10.2174/138920308785915245

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MeSH Terms: Amino Acid Sequence, Anthrax, Anti-HIV Agents, Cardiovascular Diseases, Computational Biology, Drug Design, Forecasting, HIV-1, Humans, Influenza A Virus, H5N1 Subtype, Molecular Sequence Data, Mutation, Proteins, Risk Factors, Structure-Activity Relationship