AMIN domains have a predicted role in localization of diverse periplasmic protein complexes.

Robson Francisco de Souza, Vivek Anantharaman, Sandro José de Souza, L Aravind, Frederico J Gueiros-Filho

Journal: Bioinformatics (Oxford, England) 2008;24(21):2423-6

PMID: 18723522

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Abstract

We describe AMIN (Amidase N-terminal domain), a novel protein domain found specifically in bacterial periplasmic proteins. AMIN domains are widely distributed among peptidoglycan hydrolases and transporter protein families. Based on experimental data, contextual information and phyletic profiles, we suggest that AMIN domains mediate the targeting of periplasmic or extracellular proteins to specific regions of the bacterial envelope.

Address: Departamento de Bioquímica, Universidade de São Paulo, São Paulo, Brazil.

DOI: 10.1093/bioinformatics/btn449

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MeSH Terms: Amino Acid Sequence, Bacterial Proteins, Models, Genetic, Molecular Sequence Data, Periplasmic Proteins, Protein Structure, Secondary, Protein Structure, Tertiary, Sequence Alignment