Role of LKB1 in lung cancer development.

L Makowski, D N Hayes

Journal: British journal of cancer 2008;99(5):683-8

PMID: 18728656

Free Full Text on PubMed Central View on PubMed

Abstract

Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation.

Address: Division of Endocrinology, Department of Medicine, Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Metabolism, and Nutrition, Durham, NC, USA.

DOI: 10.1038/sj.bjc.6604515