Membrane redox state and apoptosis: death by peroxide.

Joseph Loscalzo

Journal: Cell metabolism 2008;8(3):182-3

PMID: 18762018

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Abstract

Membrane redox state is governed by the complex interplay between oxidation of unsaturated fatty acids and lipophilic antioxidants. In this issue of Cell Metabolism, Seiler et al. (2008) show that a lipid oxidase, 12/15-lipoxygenase, and a membrane antioxidant enzyme, glutathione peroxidase-4, interact to regulate a novel redox-dependent cell death pathway.

Address: Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Harvard Medical School, Boston, MA 02118-2394, USA. [email protected]

DOI: 10.1016/j.cmet.2008.08.004

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MeSH Terms: Apoptosis, Arachidonate 12-Lipoxygenase, Arachidonate 15-Lipoxygenase, Cell Death, Cell Membrane, Glutathione Peroxidase, Lipid Peroxides, Oxidation-Reduction, Oxidative Stress, Phospholipid Hydroperoxide Glutathione Peroxidase, Signal Transduction