Central neurocytoma responsive to topotecan, ifosfamide, carboplatin.

Elham Amini, Tina Roffidal, Alice Lee, Gregory N Fuller, Anita Mahajan, Leena Ketonen, Nathan Kobrinsky, Mitchell S Cairo, Robert J Wells, Johannes E A Wolff

Journal: Pediatric blood & cancer 2008;51(1):137-40

PMID: 18338396

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Abstract

A 5-year-old male presented with spinal cord drop metastasis from a recurrent neurocytoma. Topotecan (0.5 mg/m(2)) and carboplatin (250 mg/m(2)) were administered on days 1-3 and ifosfamide (1,800 mg/m(2)) on days 1-5, every 21 days, for three cycles and resulted in complete response without severe complications. A literature review yielded 20 patients with central neurocytoma but no complete responses. The complete response of central neurocytoma to chemotherapy only reported here should be helpful to those caring for patients with this rare tumor.

Address: Department of Pediatrics, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

DOI: 10.1002/pbc.21551

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MeSH Terms: Antineoplastic Combined Chemotherapy Protocols, Carboplatin, Child, Preschool, Disease-Free Survival, Humans, Ifosfamide, Magnetic Resonance Imaging, Male, Neurocytoma, Remission Induction, Topotecan