Acute Akinesia, an unusual complication in Parkinson's Disease: a case report.

Marco Simonetto, Laura Ferigo, Luca Zanet, Livio Capus, Lucia Antonutti, Marino Zorzon, Gilberto Pizzolato

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2008;29(3):181-3

PMID: 18612768

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Abstract

Acute akinesia (AA) is a rare but serious complication of Parkinson's Disease (PD) 0,3% of all patients with PD). It can be related to infectious condition, surgery, or treatment changes. AA can completely recover or result in some motor deficits, and, in the most severe forms, it may lead to untreatable complications and death. Here we report the case of a 67-year-old man with PD who rapidly developed a severe akinetic state with rise of temperature (39 degrees C) and creatine phosphokinase concentration (up to 5000 mg/dL). After excluding infection diseases and other pathologies, we suspected AA and added apomorphine 50mg/die s.c. and ondansetron 8 mg i.v. The patient responded to treatment and ameliorated in few weeks.

Address: Department of Experimental and Clinical Medicine and Experimental and Clinical Neurosciences, University of Trieste, Strada di Fiume 447, Trieste, Italy. [email protected]

DOI: 10.1007/s10072-008-0933-2

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MeSH Terms: Acute Disease, Aged, Antiparkinson Agents, Apomorphine, Basal Ganglia Diseases, Creatine Kinase, Disease Progression, Dopamine Agonists, Drug Resistance, Fever, Humans, Male, Ondansetron, Parkinson Disease, Respiratory Insufficiency, Serotonin Antagonists, Syndrome, Treatment Outcome