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Syndromes, disorders and maternal risk factors associated with neural tube defects (IV).

Chih-Ping Chen

Journal: Taiwanese journal of obstetrics & gynecology 2008;47(2):141-50

PMID: 18603497

Free Full Text on Elsevier Science View on PubMed

Abstract

Fetuses with neural tube defects (NTDs) may be associated with maternal and fetal risk factors. This article provides a comprehensive review of maternal and fetal risk factors associated with NTDs, such as infertility, periconceptional clomiphene use and assisted reproductive technology, periconceptional folic acid deficiency and effects of folic acid supplementation and fortification on NTD rates, periconceptional vitamin B12 deficiency, single nucleotide polymorphisms and polymorphisms in genes of folate metabolism, and maternal autoantibodies to folate receptors. NTDs associated with maternal and fetal risk factors are an important cause of NTDs. Perinatal identification of NTDs should alert the clinician to the maternal and fetal risk factors associated with NTDs, and prompt a thorough etiologic investigation and genetic counseling.

Address: Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan. [email protected]
DOI: 10.1016/S1028-4559(08)60071-6

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MeSH Terms: Betaine-Homocysteine S-Methyltransferase, Clomiphene, Female, Fertility Agents, Female, Folic Acid, Folic Acid Deficiency, Humans, Infertility, Neural Tube Defects, Polymorphism, Single Nucleotide, Pregnancy, Pregnancy Outcome, Prenatal Exposure Delayed Effects, Risk Factors
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