MLL insertion with MLL-MLLT3 gene fusion in acute leukemia: case report and review of the literature.

Gwendoline Soler, Isabelle Radford, Claus Meyer, Rolf Marschalek, Chantal Brouzes, David Ghez, Serge Romana, Roland Berger

Journal: Cancer genetics and cytogenetics 2008;183(1):53-9

PMID: 18474298

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Abstract

A new chromosomal insertion involving the MLL gene was detected by fluorescence in situ hybridization in a patient with acute myeloblastic leukemia (AML) and a t(9;11)(p21;q13). Genomic polymerase chain reaction confirmed the MLL-MLLT3 gene fusion. A review of the literature on MLL insertions shows that the opposite orientation of the genes involved in the fusion plays a role in the genesis of the rearrangement in most of the cases reported.

Address: Service de cytogénétique, Assistance PubliqueeHôpitaux de Paris, Centre Hospitalier Universitaire Necker-Enfants Malades, 149 rue de Sèvres, 75743, paris Cedex 15, France.

DOI: 10.1016/j.cancergencyto.2008.01.016

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MeSH Terms: Adult, Amino Acid Sequence, Base Sequence, Chromosome Breakage, Cytogenetic Analysis, Female, Histone-Lysine N-Methyltransferase, Humans, Leukemia, Myeloid, Acute, Molecular Sequence Data, Mutagenesis, Insertional, Myeloid-Lymphoid Leukemia Protein, Nuclear Proteins, Oncogene Proteins, Fusion