Future target molecules for influenza treatment.

N Uchide, H Toyoda

Journal: Mini reviews in medicinal chemistry 2008;8(5):491-5

PMID: 18473937

Abstract

Induction of apoptosis and pro-inflammatory cytokine gene expression in influenza virus-infected cells activates production of toxic superoxide by macrophages. Pyrrolidine dithiocarbamate and nordihydroguaiaretic acid inhibit influenza virus proliferation and scavenge superoxide. These results suggest that they can be potential candidates for a drug of choice for influenza chemotherapy.

Address: Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. [email protected]

DOI: 10.2174/138955708784223530

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MeSH Terms: Apoptosis, Cell Proliferation, Cytokines, Gene Expression, Humans, Influenza, Human, Masoprocol, Pyrrolidines, Superoxides, Thiocarbamates