Early signals after stretch leading to cardiac hypertrophy. Key role of NHE-1.

Horacio E Cingolani, Nestor G Perez, Ernesto A Aiello, Irene L Ennis, Carolina D Garciarena, Maria C Villa-Abrille, Raul A Dulce, Claudia I Caldiz, Alejandra M Yeves, Maria V Correa, Mariela B Nolly, Gladys Chiappe de Cingolani

Journal: Frontiers in bioscience : a journal and virtual library 2008;13():7096-114

PMID: 18508719

View on PubMed

Abstract

The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCX(rev)), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.

Address: Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Calle 60 y 120, 1900 La Plata, Argentina. [email protected]

DOI: 10.2741/3213

Link outs

Free resources

Miscellaneous:

https://assays.cancer.gov/CPTAC-1005

MeSH Terms: Adult, Angiotensin II, Biomechanical Phenomena, Cardiomegaly, Heart Ventricles, Humans, Hypertrophy, Right Ventricular, Obesity, Pressoreceptors, Reactive Oxygen Species, Signal Transduction, Sodium-Hydrogen Exchangers, Ventricular Function