Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.

Hugues de Rocquigny, Volodymyr Shvadchak, Sergiy Avilov, Chang Zhi Dong, Ursula Dietrich, Jean-Luc Darlix, Yves Mély

Journal: Mini reviews in medicinal chemistry 2008;8(1):24-35

PMID: 18220982

Abstract

The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc ejectors inhibit NC functions, but with limited specificity. New classes of molecules competing with NC or its viral nucleic acid and enzyme partners are reviewed here.

Address: Institut Gilbert Laustriat, Photophysique des interactions moléculaires, UMR 7175 CNRS, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg 1, 74, Route du Rhin, 67401 ILLKIRCH Cedex, France.

DOI: 10.2174/138955708783331603

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MeSH Terms: Anti-HIV Agents, Drug Delivery Systems, HIV-1, Humans, Models, Biological, Nucleocapsid Proteins, Structure-Activity Relationship, Virus Replication, Zinc Fingers