Processing of DNA replication and repair intermediates by the concerted action of RecQ helicases and Rad2 structure-specific nucleases.

Robert M Brosh, Sudha Sharma, Joshua A Sommers

Journal: Protein and peptide letters 2008;15(1):89-102

PMID: 18221018

Abstract

Processing of DNA replication and repair intermediates is a critical aspect of genome stability maintenance. The coordinated action of RecQ-like helicases with structure-specific nucleases such as Flap Endonuclease 1 plays an important role in the processing of certain DNA structures associated with the replication fork, DNA repair, or telomeres. We will summarize our current understanding of how and in what context these interactions take place, with a particular emphasis on the mechanisms of RecQ helicases in processing of key DNA replication and repair intermediates by their protein interactions with FEN-1 and related structure-specific nucleases.

Address: Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.

DOI: 10.2174/092986608783330369

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MeSH Terms: Amino Acid Sequence, Catalytic Domain, DNA Repair, DNA Repair Enzymes, DNA Replication, Exodeoxyribonucleases, Flap Endonucleases, Humans, Molecular Sequence Data, RecQ Helicases, Sequence Alignment, Werner Syndrome Helicase