Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases.

Li-Te Chin, Chishih Chu, Han-Min Chen, Ding-Wei Wang, Shuen-Kuei Liao

Journal: Chang Gung medical journal 2008;31(1):1-15

PMID: 18419049

Free Full Text on Chang Gung Medical Hospital View on PubMed

Abstract

CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy for over a decade. However, the precise roles played by this molecule continue to emerge. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg). In this review, we discuss the recent progress and main features of monoclonal antibodies (mAbs) targeting CD152 and examine how each mAb prepared to a distinct epitope may impact differently upon CD152 modulation depending on its demonstrated regulatory role acting as an agonist, antagonist, or inverse agonist.

Address: Graduate Institute of Life Science, Fu-Jen Catholic University, Taipei, Taiwan, ROC.

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Full Text Sources:

http://cgmj.cgu.edu.tw/3101/310101.pdf

Medical:

https://medlineplus.gov/autoimmunediseases.html

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MeSH Terms: Amino Acid Sequence, Antibodies, Monoclonal, Antigens, CD, Antigens, Differentiation, Autoimmune Diseases, B7-1 Antigen, CD28 Antigens, CTLA-4 Antigen, Cell Adhesion, Humans, Molecular Sequence Data, Neoplasms, Protein Conformation, Signal Transduction, T-Lymphocytes, Regulatory