Medical implications of benzimidazole derivatives as drugs designed for targeting DNA and DNA associated processes.

Santanu Bhattacharya, Padmaparna Chaudhuri

Journal: Current medicinal chemistry 2008;15(18):1762-77

PMID: 18691037

Abstract

Properties of benzimidazole and its derivatives have been studied for over hundred years; special interest of researchers triggered by the fact that 5,6-dimethylbenzimidazole is a component of naturally occurring vitamin B(12). Several antihelminthic, antacid and antibacterial drugs are known which have benzimidazole moiety as their essential constituent. Additionally, several bis- and tris-benzimidazole based systems are well-known for their interaction with DNA and interference with several DNA associated processes. This account gives an overview of the benzimidazole based systems and their relevance in medicinal chemistry.

Address: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India. [email protected]

DOI: 10.2174/092986708785133013

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MeSH Terms: Alkylating Agents, Anti-Infective Agents, Antiviral Agents, Benzimidazoles, Chemistry, Chemistry, Pharmaceutical, DNA, Drug Design, Humans, Models, Chemical, Molecular Structure, Neoplasms, Technology, Pharmaceutical