Successful treatment of multi-resistant Pseudomonas aeruginosa osteomyelitis after allogeneic bone marrow transplantation with a combination of colistin and tigecycline.

Marta Stanzani, Fabio Tumietto, Maria Benedetta Giannini, Giuseppe Bianchi, Anna Nanetti, Nicola Vianelli, Mario Arpinati, Maddalena Giovannini, Francesca Bonifazi, Giuseppe Bandini, Michele Baccarani

Journal: Journal of medical microbiology 2008;56(Pt 12):1692-1695

PMID: 18033842

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Abstract

A case of osteomyelitis caused by multidrug-resistant Pseudomonas aeruginosa is reported in a patient who underwent allogeneic bone marrow transplantation for acute lymphoblastic leukaemia. The patient was successfully treated by prolonged administration of a full dose of colistin and tigecycline, and surgical curettage with the positioning of resorbable calcium sulfate pellets loaded with colistin.

Address: Institute of Hematology and Clinical Oncology 'Lorenzo e Ariosto Serágnoli', S. Orsola-Malpighi Hospital, University of Bologna, Italy.; Division of Infectious Diseases, S. Orsola-Malpighi Hospital, University of Bologna, Italy.; Rizzoli Orthopaedic Institutes, 5th Division, University of Bologna, Italy.; Department of Clinical and Experimental Medicine, Section of Microbiology S. Orsola-Malpighi Hospital, University of Bologna, Italy.

DOI: 10.1099/jmm.0.47286-0

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MeSH Terms: Adult, Anti-Bacterial Agents, Bone Marrow Transplantation, Colistin, Drug Resistance, Multiple, Bacterial, Drug Therapy, Combination, Female, Humans, Minocycline, Osteomyelitis, Pseudomonas Infections, Pseudomonas aeruginosa, Tigecycline, Transplantation, Homologous