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The primary cilia, a 'Rab-id' transit system for hedgehog signaling.

Anthony E Oro

Journal: Current opinion in cell biology 2008;19(6):691-6

PMID: 18061425

Free Full Text on PubMed Central View on PubMed

Abstract

Intense focus has been centered around how the primary cilia transduces the hedgehog (Hh) signal from smoothened (Smo) to the Gli transcription factors. New data indicate that ligand and signaling lipids help regulate small GTPase-dependent accumulation and activity of signaling components.

Address: Stanford University, School of Medicine, Stanford, CA 94305, USA. [email protected]
DOI: 10.1016/j.ceb.2007.10.008

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MeSH Terms: Cilia, Hedgehog Proteins, Humans, Monomeric GTP-Binding Proteins, Receptors, G-Protein-Coupled, Signal Transduction, Smoothened Receptor, Transcription Factors, Zinc Finger Protein GLI1
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