Myofibroblastic sarcoma of the nasal cavity and paranasal sinus: a clinicopathologic study of 6 cases and review of the literature.

Guo-Zhao Meng, Hong-Ying Zhang, Hong Bu, Guang-Hua Yang, Xian-Liang Zhang, Guo Yang

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2007;104(4):530-9

PMID: 17142072

Full Text on Elsevier Science View on PubMed

Abstract

OBJECTIVE

We describe the clinicopathologic features of 6 cases of myofibroblastic sarcoma (MS) occurring in the nasal cavity and paranasal sinus.

STUDY DESIGN

The paraffin-embedded tissues of 6 cases of MS were stained immunohistochemically and examined by electron microscopy.

RESULTS

Clinically, a painless enlarging mass was the most common symptom, followed by the nasal obstruction, epistaxis, copious rhinorrhea, and proptosis. Histologically, the tumors showed a diffusely infiltrative growth pattern and consisted mainly of spindle cells with abundant eosinophilic cytoplasm. The hypocellular myxoid areas and the hypercellular fibrous areas were identified. Immunohistochemically, all 6 tumors were positive for vimentin, alpha-smooth muscle actin, calponin, and fibronectin. Ultrastructural examination in 3 cases showed characteristic features of myofibroblast. Follow-up in 6 patients revealed high local recurrence rate (6 out of 6).

CONCLUSION

Myofibroblastic sarcoma of the nasal cavity and paranasal sinus exhibit diverse histologic appearances and a strong aggressive behavior.

Address: Department of Pathology and Laboratory of Pathology, West China Hospital, Zichuan University, Chengdu City, PR China

DOI: 10.1016/j.tripleo.2006.08.021

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MeSH Terms: Actins, Adolescent, Adult, Aged, Calcium-Binding Proteins, Fatal Outcome, Female, Fibronectins, Humans, Immunoenzyme Techniques, Male, Microfilament Proteins, Middle Aged, Myosarcoma, Neoplasm Invasiveness, Nose Neoplasms, Paranasal Sinus Neoplasms, Vimentin, Calponins