Primary intracranial squamous cell carcinoma arising in an epidermoid cyst--a case report and review of literature.

Shipra Agarwal, Arvind Rishi, Vaishali Suri, M C Sharma, G D Satyarthi, Ajay Garg, Chitra Sarkar

Journal: Clinical neurology and neurosurgery 2008;109(10):888-91

PMID: 17826893

Full Text on Elsevier Science View on PubMed

Abstract

Primary intracranial squamous cell carcinoma is extremely rare, with most of the cases arising from malignant transformation of an epidermoid or a dermoid cyst. We report here a case of a 45-year-old male patient who presented with 1-month history of intermittent headache and recent onset of altered sensorium. Imaging revealed a midline posterior fossa mass lesion compressing the fourth ventricle and causing hydrocephalus. A provisional diagnosis of dermoid cyst was considered. Histopathological examination revealed a squamous cell carcinoma possibly arising from an underlying epidermoid cyst. This entity is being reported for its rarity.

Address: Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

DOI: 10.1016/j.clineuro.2007.07.026

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MeSH Terms: Brain Diseases, Calcinosis, Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Cholesterol, Cranial Fossa, Posterior, Diagnosis, Differential, Epidermal Cyst, Fourth Ventricle, Humans, Keratins, Male, Middle Aged, Skull Base Neoplasms, Tomography, X-Ray Computed