Role of rafts in neurological disorders.

U Meza, C Romero-Méndez, S Sánchez-Armáss, A A Rodríguez-Menchaca

Journal: Neurologia 2023;38(9):671-680

PMID: 37858892

Free Full Text on Ediciones Doyma, S.L. View on PubMed

Abstract

INTRODUCTION

Rafts are protein-lipid structural nanodomains involved in efficient signal transduction and the modulation of physiological processes of the cell plasma membrane. Raft disruption in the nervous system has been associated with a wide range of disorders.

DEVELOPMENT

We review the concept of rafts, the nervous system processes in which they are involved, and their role in diseases such as Parkinson's disease, Alzheimer disease, and Huntington disease.

CONCLUSIONS

Based on the available evidence, preservation and/or reconstitution of rafts is a promising treatment strategy for a wide range of neurological disorders.

Address: Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México. Electronic address: [email protected].; Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México. Electronic address: [email protected].; Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México. Electronic address: [email protected].; Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México. Electronic address: [email protected].

DOI: 10.1016/j.nrleng.2023.10.003

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MeSH Terms: Humans, Caveolae, Membrane Microdomains, Cholesterol, Cell Membrane, Alzheimer Disease