Using saline solutions for ACE washouts.

S-J Hyde, M G Coulthard, B Jaffray, M E Vallely, S M Harding

Journal: Archives of disease in childhood 2008;93(2):149-50

PMID: 17881423

Abstract

We had found that twice-normal saline (2NS) antegrade continence enema (ACE) lavages were better than with normal saline (NS) but caused unpleasant symptoms. We therefore undertook a double-blind crossover study comparing water, NS and 2NS in four children. NS produced no disturbances, but water caused a transient fall in plasma osmolality of 7.3 mosmol/kg at 20 min, and falls in urine sodium and osmolality. With 2NS, the plasma sodium rose by 2.5 mmol/l, the plasma proteins rose by 2.3 g/l and the lavage fluid sodium fell, suggesting that about 10 ml/kg of plasma water had moved into the colonic lumen, and two subjects became thirsty. Five other children did home testing. Their home-produced saline was too concentrated and varied widely, and they found that 30 ml/kg of NS produced the same washout result as 20 ml/kg of 2NS. Carefully made-up NS should be used for lavage, increasing volumes if necessary.

Address: Medical School, Newcastle University, Newcastle, UK.

DOI: 10.1136/adc.2007.123489

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MeSH Terms: Adolescent, Child, Cross-Over Studies, Double-Blind Method, Enema, Fecal Incontinence, Female, Home Nursing, Humans, Male, Osmolar Concentration, Sodium, Sodium Chloride, Therapeutic Irrigation, Treatment Outcome, Water