Potential biochemical therapy of glioma cancer.

Li-Tian Yin, Yue-Jun Fu, Qiao-Ling Xu, Jun Yang, Zeng-Li Liu, Ai-Hua Liang, Xiao-Jun Fan, Cheng-Gang Xu

Journal: Biochemical and biophysical research communications 2007;362(2):225-9

PMID: 17707767

Full Text on Elsevier Science View on PubMed

Abstract

Glioma is a highly invasive, rapidly spreading form of brain cancer that is resistant to surgical and medical treatment. The recent progresses made in intracellular and ion channels of glioma cells provide a potential new approach for biochemical therapy of brain tumor. In this paper, we reviewed clinical data on chemotherapy by temozolomide and results from new studies on voltage-gated potassium channels, large-conductance Ca(2+)-activated K(+) channels, volume-activated chloride channels, glioma-specific chloride channel and their modulators. These new findings may represent future directions for brain tumor studies and treatment.

Address: Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, PR China.

DOI: 10.1016/j.bbrc.2007.07.167

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MeSH Terms: Antineoplastic Agents, Alkylating, Brain Neoplasms, Dacarbazine, Glioma, Humans, Indoles, Models, Biological, Molecular Structure, Potassium Channel Blockers, Potassium Channels, Calcium-Activated, Temozolomide