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Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state.

Jason S Carroll, Kelly A Green

Journal: Nature reviews. Cancer 2007;7(9):713-22

PMID: 17721435

Full Text on Nature Publishing Group View on PubMed

Abstract

Oestrogen receptor-alpha (ERalpha)-regulated transcription in breast cancer cells involves protein co-factors that contribute to the regulation of chromatin structure. These include co-factors with the potential to regulate histone modifications such as acetylation or methylation, and therefore the transcriptional state of target genes. Although much of the information regarding the interaction of specific co-factors with ER has been generated by studying specific promoter regions, we now have an improved understanding of the nature of these interactions and are better placed to relate these with ER activity and potentially with the activity of breast cancer drugs, including tamoxifen.

Address: Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK.
DOI: 10.1038/nrc2211

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MeSH Terms: Amino Acid Sequence, Carrier Proteins, Chromatin, Chromatin Immunoprecipitation, Corticosterone, Estrogen Receptor alpha, Humans, Models, Biological, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Repressor Proteins, Tamoxifen, Transcription, Genetic, Transcriptional Activation, Trefoil Factor-1, Tumor Suppressor Proteins, p300-CBP Transcription Factors
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