Offering surprises: TCA cycle regulation in Corynebacterium glutamicum.

Michael Bott

Journal: Trends in microbiology 2007;15(9):417-25

PMID: 17764950

Full Text on Elsevier Science View on PubMed

Abstract

Corynebacterium glutamicum, a Gram-positive soil bacterium, is used for the production of l-glutamate and l-lysine, both of which are derived from intermediates of the tricarboxylic acid (TCA) cycle. Recent studies have revealed that this amphibolic pathway is subject to complex regulation not only at the transcriptional level, but also at the post-transcriptional level. The latter involves serine/threonine protein kinase G and its target protein OdhI. Depending on its phosphorylation state, OdhI inhibits the 2-oxoglutarate dehydrogenase complex. This new type of TCA cycle control will be reviewed here together with regulation at the level of gene expression.

Address: Institut für Biotechnologie 1, Forschungszentrum Jülich, D-52425 Jülich, Germany. [email protected]

DOI: 10.1016/j.tim.2007.08.004

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MeSH Terms: Acetates, Aconitate Hydratase, Amino Acid Sequence, Amino Acids, Base Sequence, Citric Acid Cycle, Corynebacterium glutamicum, Gene Expression Regulation, Bacterial, Ketoglutarate Dehydrogenase Complex, Molecular Sequence Data, Phosphorylation, Transcription, Genetic