The functions and applications of extracellular vesicles derived from Mycobacterium tuberculosis.

Yujie Li, Yingfen Qian, Nan Wang, Dewen Qiu, Hui Cao, Yihua Wang, Hao Luo, Xiaodong Shen, Hanwei Cui, Jianjun Wang, Hong Zhu

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023;168():115767

PMID: 37865994

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Abstract

Extracellular vesicles (EVs) originating from bacteria function critical roles in bacterial biologic physiology and host-pathogen interactions. Mycobacterium tuberculosis (M. tuberculosis) produces EVs both in vitro and in vivo, with membrane-bound nanoparticles facilitating the transmission of biological molecules including lipids, proteins, nucleic acids and glycolipids, while interacting remotely with the host. Although studies of EVs in mycobacterial infections is still in its infancy, it has already revealed an entirely new aspect of M. tuberculosis-host interactions that may have implications for tuberculosis (TB) pathogenesis. In this review, we discuss the significant functions of M. tuberculosis EVs in elucidating the mechanisms underlying vesicle biogenesis and modulating cellular immune responses, as well as the recent advances and challenges in the development of novel preventive and therapeutic or diagnostic strategies against TB.

Address: Department of Clinical Laboratory, Kunshan Hospital Affiliated to Jiangsu University, Suzhou 215300, PR China.; Department of Clinical Laboratory, The Fourth People's Hospital of Kunshan, Suzhou, Jiangsu 215300, PR China.; Department of Clinical Laboratory, Jiangxi Maternal and Child health hospital Maternal and Child heath hospital of Nanchang college, Nanchang 215300, PR China.; Department of Food and Nutrition Safety, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, PR China.; Department of Clinical Laboratory, Kunshan Jinxi People's Hospital, Suzhou 215300, PR China.; Department of Clinical Laboratory, Kunshan Second People's Hospital, Suzhou 215300, PR China.; Penglang Community Health Service Center of Kunshan Economic and Technological Development Zone, Suzhou 215300, PR China.; Department of Central Laboratory, The Fourth People's Hospital of Shenzhen, Shenzhen 518118, PR China. Electronic address: [email protected].; Department of Clinical Laboratory, Kunshan Hospital Affiliated to Jiangsu University, Suzhou 215300, PR China. Electronic address: [email protected].; Department of Clinical Laboratory, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213000, PR China. Electronic address: [email protected].

DOI: 10.1016/j.biopha.2023.115767

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MeSH Terms: Humans, Mycobacterium tuberculosis, Tuberculosis, Immunity, Cellular, Extracellular Vesicles