Allogenic Cord Blood Transfusion in Preterm Infants.

Luciana Teofili, Patrizia Papacci, Carmen Giannantonio, Maria Bianchi, Caterina Giovanna Valentini, Giovanni Vento

Journal: Clinics in perinatology 2023;50(4):881-893

PMID: 37866854

Full Text on Elsevier Science View on PubMed

Abstract

Repeated red blood cell (RBC) transfusions in preterm neonates cause the progressive displacement of fetal hemoglobin (HbF) by adult hemoglobin. The ensuing increase of oxygen delivery may result at the cellular level in a dangerous condition of hyperoxia, explaining the association between low-HbF levels and retinopathy of prematurity or bronchopulmonary dysplasia. Transfusing preterm neonates with RBC concentrates obtained from allogeneic umbilical blood is a strategy to increase hemoglobin concentration without depleting the physiologic HbF reservoir. This review summarizes the mechanisms underlying a plausible beneficial impact of this strategy and reports clinical experience gathered so far in this field.

Address: Transfusion Medicine Department, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo Gemelli 8, Rome, Italy. Electronic address: [email protected].; Neonatal Intensive Care Unit, Fondazione Policlinico A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo Gemelli 8, Rome, Italy.; Neonatal Intensive Care Unit, Fondazione Policlinico A. Gemelli IRCCS, Largo Gemelli 8, Rome, Italy.; Transfusion Medicine Department, Fondazione Policlinico A. Gemelli IRCCS, Largo Gemelli 8, Rome, Italy.

DOI: 10.1016/j.clp.2023.07.005

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MeSH Terms: Infant, Newborn, Humans, Infant, Premature, Blood Transfusion, Fetal Blood, Erythrocyte Transfusion, Hemoglobins